Position: Head of Biochemistry division, Department of Chemistry and Biochemistry

Medical University – Pleven,

AcademicQualifications:        PhD in Biochemistry; DSc in Biochemistry

Academic degree: Professor

PHD thesis: "Thermal stability of fibrillar collagens, influence of various chemical factors"

The scientific degree "Doctor of Science";

Dissertation "A new insight at the role of genetic and non-genetic risk factors in the pathogenesis of thrombotic events in patients with venous thromboembolism and reproductive problems"

Academic Career:     

• 1997-Head of Biochemistry division,
• 1997-Senior Lecturer of Biochemistry Department
• 2005-   2013 Head of Chemistry and Biochemistry Department
• 2000-   Senior Lecturer of Pathobiochemistry course
• 2000-2008-Institutional ECTS – coordinator,
• 2000-2009-University coordinator of Socrates/ Erasmus Programme of Directorate-General for Education and Culture, EU,
• 2005-Co-director of Educational Programme of ESPEN:LLL programme in Clinical Nutrition and Metabolism
• 2009-2013-Vice Dean of Faculty of Medicine
• 2009-2013-Responsible for student recruitment
• 2009-2013-Head of Accreditation commission of the Faculty of Medicine

Coordinated EU  PROJECTS

• 2000 – 2002                Pilot Project No. BG/00/B/P/PP/132100
• Improvement of practical skills in molecular biology and analytic biochemistry in medical training. Selected Methods of DNA Analysis,  EUROPEAN COMMISSION, Directorate-General for Education and Culture,
• Selected Methods of DNA Analysis, Lipid Analysis  and of Protein Analysis Protein Analysis
• 2003 – 2005                Pilot Project № BG/03/B/F/PP-166039
• „Life Long Learning: Nutrition at the Level of Molecular Medicine”, EUROPEAN COMMISSION, Directorate-General for
• Education and Culture, Vocational training, Implementation of the Leonardo da Vinci programme , developed in collaboration and extreme input of ESPEN
• Educational Web-Portal of the project: www.lllnutrition.com
• Web site www.lll-nutrition.com/proj

• 2004 – 2006                Pilot project BG/04/B/F/PP-166016
• Training of Medical Students and Young Doctors as Promoters of Prevention of Drug Abuse
• EUROPEAN COMMISSION, Directorate-General for Education and Culture
• Vocational training, Implementation of the Leonardo da Vinci programme
• Web site of the project: www.drugs-mesada.com.
• Drug Abuse Treatment and Prevention,  e-learning programme for medical students and young doctorsStudy Manual for Medical Students and Young Doctors

• 2007 – 2009                Transfer of innovation project: LLP-LDV-TOI-07-BG-166014.
• Virtual portal for training of trainers in nutrition, ICT and innovative skills.,
• Informational Web-site of the project: http://www.lllnutrition.com/tlllproj.
• Educational Web portal for training of trainers

OTHER PROJECTS of EUROPEAN COMMISSION

• 2000 – 2001 - Project № BG/00/A/F/EX/132099
• 2002 - Project № 80231-IC-1-2002-1-BG-ERASMUS-EUC-1
• 2007 - Project № 80231-IC-1-2002-1-BG-ERASMUS-EUCХ-1,  
• University Charter for the period of 2003 - 2007

Scientific Areas:

In the field of DNA analysis, Metabolism  and Clinical nutrition:

• Inherited venous and arterial thrombosis. Thrombophilia in patients with deep vein thrombosis,  pulmonary embolism, the role of genetic polymorphisms  SNP rs5918ITGB3, rs1799889 (-), rs6025 and rs1799963 in the pathogenesis of thrombotic events and the association with changes in platelet activation
• Inherited  Thrombophilia in women with miscarriages. The role of genetic polymorphisms  SNP rs5918ITGB3, rs1799889 (-), rs6025 and rs1799963 in the pathogenesis of thrombotic events and the association with changes in platelet activation in women with reproductive problems and PCOS
• Investigation of activity, morphological and mechanical characteristics of platelets and relation to patient genotype - a new approach in assessing the importance of the carriage of prothrombotic polymorphisms for the development of incidents
• In the field of connective tissue protein (collagen), change in structure and properties in pathological processes such as atherosclerosis and diabetes. Blood and CSF proteomes.
• Drug abuse  prevention,
• Clinical nutrition and Metabolism in chronic pulmonary and cardiovascular disease

Publications:

Number of scientific papers - a total of 236 of which 2 dissertations, 92 published articles in scientific journals (34 International and 60 Bulgarian), 16 co-authorship in books chapters and 124 papers with published abstracts (65 in Bulgaria and 59 abroad).

The total number of citation is 436, of which 405 in foreign and 31 in Bulgarian magazines. The total impact factor is 75,086 (IF of publications - 48,247 and IF of abstracts - 26,839).

Awards:

• Three awards of the Ministry of education for the Excellence in the European project development
• In 2017 was awarded with international prize  for the contribution to the development of education in clinical nutrition.

Membership in scientific organizations:

• Union of Scientists in Bulgaria),
• ESPEN (European Association for Clinical Nutrition and Metabolism)
• BULSPEN Bulgarian Association of Clinical Nutrition and Metabolism
• Federation of European Biochemical Societies - FEBS
• An International Association for Medical Education - AMEE
• 2004 - Deputy President of BULSPEN
• 2004 - Board of Directors of the LLL - ESPEN Educational Program.
• 2005 - Co-Director of a Clinical Nutrition Training Program in the framework of the European Lifelong Learning Initiative.
• Member of Editorial Board of Clinical Nutrition and Metabolism (ESPEN), Nutrition, (ASPEN), Clinical Nutrition of (BULSPEN)

Scientific Projects:  MU-Pleven & Ministry of education

• 2005-  Study of plasma levels of homocysteine and congenital enzyme defects leading to heperhomotsisteinemiya in patients with arterial and venous thrombosis

• Study of genetic deterministic increased platelet aggregation in patients with cerebral vascular disease

• 2006 - Investigation of genetic thrombophilic defects and assessment of their contribution to the risk for trombotichnichni complications in patients with essential thrombocythaemia

• Research on the importance of inherited genetic factors for primary pre-eclampsia in pregnant women

• 2007 -  Investigation of the 4G/5G polymorphism in the gene of plasminogen activator inhibitor - 1 (PAI-1) as a factor for deep vein thrombosis
   
• Study the importance of carriage of A1/A2 polymorphism
  gene platelet glycoprotein IIb / IIIa for the development of very early fetal loss

• 2008 -  Epidemiological study of congenital and acquired risk factors for development of COPD

• Investigation of congenital and acquired factors for pulmonary thromboembolism, contribution of nutrition

• 2009 - Investigation the relationship between the status of malnutrition and chronic inflammation in patients with COPD.
   
• Early and late recurrent spontaneous abortions in female carriers of the polymorphism 4g/5g gene plasminogen activator inhibitor type 1 (pai-1)
   
• Interaction between inherited and acquired factors in the multifactorial etiology of venous thromboembolism
   
• 2010 - Early recurrent pregnancy loss in women and their relationship with levels of polyunsaturated fatty acids and occurrence  of polymorphism FADS1 and FADS2
   
• Study of the levels of docosahexaenoic, eicosapentaenoic omega-3 polyunsaturated fatty acids and their precursor in cell membranes in  patients with hypertension